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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RPS6KA5
All Species:
13.64
Human Site:
Y278
Identified Species:
20
UniProt:
O75582
Number Species:
15
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75582
NP_004746.2
802
89865
Y278
I
L
K
S
E
P
P
Y
P
Q
E
M
S
A
L
Chimpanzee
Pan troglodytes
XP_001140389
894
100719
Y370
I
L
K
S
E
P
P
Y
P
Q
E
M
S
A
L
Rhesus Macaque
Macaca mulatta
XP_001088246
1054
117436
Y536
I
L
K
S
E
P
P
Y
P
Q
E
M
S
A
L
Dog
Lupus familis
XP_547953
806
90703
Y285
I
L
K
S
E
P
P
Y
P
Q
E
M
S
A
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2B9
773
85721
R284
L
C
K
D
P
K
K
R
L
G
A
G
P
Q
G
Rat
Rattus norvegicus
Q63531
735
82865
E288
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506738
716
80894
E271
N
F
A
E
E
F
T
E
M
D
P
T
Y
S
P
Chicken
Gallus gallus
Q5F3L1
789
89022
R291
L
M
K
D
P
K
K
R
L
G
C
G
P
T
D
Frog
Xenopus laevis
P10665
733
82620
E288
M
P
Q
F
L
S
N
E
A
Q
S
L
L
R
A
Zebra Danio
Brachydanio rerio
Q6PFQ0
740
83378
E293
M
P
Q
F
L
S
L
E
A
Q
G
L
L
R
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3I5
1207
137026
I490
I
Q
K
E
Q
P
M
I
P
S
S
F
S
A
N
Honey Bee
Apis mellifera
XP_395099
910
102507
I296
I
L
K
T
D
P
P
I
P
S
H
L
S
P
I
Nematode Worm
Caenorhab. elegans
Q18846
772
87050
K279
Y
N
G
V
D
E
I
K
N
H
K
F
M
S
S
Sea Urchin
Strong. purpuratus
XP_786494
918
102561
N280
H
S
F
F
K
G
L
N
W
D
D
V
A
A
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q39030
471
53019
E50
D
V
F
G
P
M
P
E
A
N
S
E
E
A
C
Baker's Yeast
Sacchar. cerevisiae
P18961
677
76646
P256
I
D
V
F
A
R
I
P
S
L
L
L
P
S
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
88.1
75
93.1
N.A.
62.8
41
N.A.
82.1
89.4
40
40.5
N.A.
28.5
45.7
46.8
53.3
Protein Similarity:
100
88.5
75.1
95.1
N.A.
76.6
57.9
N.A.
86.1
94.6
57.4
57.3
N.A.
40
62.3
63
66.2
P-Site Identity:
100
100
100
100
N.A.
6.6
6.6
N.A.
6.6
6.6
6.6
6.6
N.A.
40
46.6
0
6.6
P-Site Similarity:
100
100
100
100
N.A.
13.3
26.6
N.A.
13.3
20
26.6
33.3
N.A.
46.6
73.3
20
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.2
21.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
35
38.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
7
0
0
0
25
0
7
0
7
44
13
% A
% Cys:
0
7
0
0
0
0
0
0
0
0
7
0
0
0
7
% C
% Asp:
7
7
0
13
13
0
0
0
0
13
7
0
0
0
7
% D
% Glu:
0
0
0
13
32
7
0
32
0
0
25
7
7
0
0
% E
% Phe:
0
7
13
32
0
7
0
0
0
0
0
13
0
0
0
% F
% Gly:
0
0
7
7
0
7
0
0
0
13
7
13
0
0
7
% G
% His:
7
0
0
0
0
0
0
0
0
7
7
0
0
0
0
% H
% Ile:
44
0
0
0
0
0
13
13
0
0
0
0
0
0
7
% I
% Lys:
0
0
50
0
7
13
13
7
0
0
7
0
0
0
13
% K
% Leu:
13
32
0
0
19
0
13
0
13
7
7
32
19
0
25
% L
% Met:
19
7
0
0
0
7
7
0
7
0
0
25
7
0
7
% M
% Asn:
7
7
0
0
0
0
7
7
7
7
0
0
0
0
7
% N
% Pro:
0
19
0
0
19
38
38
7
38
0
7
0
19
7
7
% P
% Gln:
0
7
19
0
7
0
0
0
0
44
0
0
0
7
0
% Q
% Arg:
0
0
0
0
0
7
0
13
0
0
0
0
0
19
0
% R
% Ser:
0
7
0
25
0
19
0
0
7
13
25
0
38
19
7
% S
% Thr:
0
0
0
7
0
0
13
0
0
0
0
7
0
7
0
% T
% Val:
0
7
7
7
0
0
0
0
0
0
0
7
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% W
% Tyr:
7
0
0
0
0
0
0
25
0
0
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _